Junctional adhesion molecule-A (JAM-A) in gynecological cancers: Current state of knowledge

Junctional adhesion molecule-A (JAM-A), also known as the F11 receptor (F11R), is one of tight junction components. JAM-A a transmembrane glycoprotein that regulates many cellular processes, i.e., angiogenesis, leukocyte transendothelial migration, intercellular permeability, epithelial-to-mesenchymal transition, and platelet activation. Of note, it involved in pathogenesis various cancer types, including gynecological cancers. Only few studies are available about this type. Observed aberrant expression cancers correlates with poor patient prognosis. To best our knowledge, conflicting roles types suggest its involvement complex tumor-type specific. The underlying molecular mechanisms pathways responsible for functions were not fully elucidated need to be identified. Finding appropriate novel biomarkers may reduce observed very high mortality rates could contribute personalized treatment development. main aim present viewpoint article report current knowledge participation malignancies.